Sildenafil or Tadalafil

Erectile dysfunction


Sexual dysfunction occurs when men are unable to achieve and maintain an erection. Approximately 40 to 65-year-old men are at greater risk for developing this condition. These days, however, ED is also affecting teenagers and young adults. Exercise, a change in lifestyle, and drugs are the best treatments for ED. In this article we will talk about choosing between Sildenafil or Tadalafil.

There are several options for treating ED with vasodilators, including Sildenafil, Tadalafil, and Vardenafil. Both Sildenafil and Tadalafil work well for treating ED. In the medical field, these two medications are extremely popular. They operate identically and similarly. Both of these medications are inhibitors of phosphodiesterase type 5 (PDE5). Patients with erectile dysfunction often ask questions such as:

We’ll look at the differences between Sildenafil and Tadalafil to answer these queries.





Sildenafil was initially introduced in 1998, making it an old medicine with well-known pros and cons all around the world. Sildenafil is the primary ingredient in Viagra. Pharma company Pfizer brought Viagra to market and was the only company permitted to supply it till 2013. Consequently, sildenafil as an adjuvant in erectile dysfunction drugs became available after its patent expired in 2013. It’s not hard to assume that when you hear the term “Sildenafil,” it refers to the same therapeutic agent that Viagra is. The generic variant is far less expensive than the brand-name variety.

Sildenafil is a vasodilator, which means it dilates blood vessels, allowing more blood to accumulate in them and so increasing erections. It inhibits phosphodiesterase 5, which is responsible for the breakdown of cGMP, the chemical that regulates blood flow in the penis. By inhibiting phosphodiesterase 5, cGMP levels rise, causing smooth muscles in capillaries to relax and dilate. As a result, sexual stimulation promotes erection.

Sildenafil is an erectile dysfunction medication that comes in the form of an oral tablet. ED should not be treated with sildenafil more than once every 24 hours. The medicine should be administered on an empty stomach within 60 minutes of taking it to have the greatest impact. Sildenafil’s effects usually persist for around four to six hours.

The usual dose of Sildenafil is 50 mg taken once a day. If the regular dose is inadequate, they can be set as 100 mg, or if moderate side effects occur, set as 25 mg.

The adverse effects of all vasodilators are nearly the same. These are some of the adverse effects of Sildenafil:



As an alternative ED drug, Cialis was first introduced by the Eli Lilly Corporation in 2003. Cialis’ active ingredient is Tadalafil. Tadalafil was patented by the company until November 2017. Similar to Viagra, other businesses are now free to produce and sell their alternative drugs after the license on Tadalafil, the main ingredient in Cialis has been revoked.

Inhibiting phosphodiesterase 5 in Tadalafil results in an increase in blood flow in the penis because it prevents cGMP from being broken down. cGMP levels rise when phosphodiesterase 5 is inhibited, causing the smooth muscle in vessels to relax and widen.

Tadalafil is available in two different formulations: one for ‘as needed’ use and another for daily use. Tadalafil is an oral medication that takes 30 minutes to take effect. Tadalafil’s effect is unaffected by a full stomach, making it easier to use because an empty stomach is not required. The most popular feature of this medicine is that it lasts for approximately 36 hours, with only one dose lasting nearly two days.

Tadalafil’s standard dose is 10 mg, however, it can be increased to 20 mg if the prescription isn’t working. Tadalafil is available in a daily use formulation for those who desire to have sex twice a week.   As a result, they are given in little dosages. The recommended starting dose is 2.5mg once daily, which can be raised to 5mg if the first dose is unsuccessful.

Below are a few of Tadalafil’s negative side effects:



Although the mechanisms of action of both medications are identical, their functionality is vastly different. Sildenafil is an oral medicine that must be taken on an empty stomach; however, Tadalafil does not require an empty stomach for administration, making it more convenient to use. Tadalafil takes 30 minutes to take effect in comparison with Sildenafil which takes nearly 60 minutes. Tadalafil is more effective at treating erectile dysfunction because of this distinction. Tadalafil lasts roughly two days or almost 36 hours, whilst sildenafil lasts 4 to 6 hours. It is very likely that the prolonged treatment duration of tadalafil draws men with ED to choose it over sildenafil.

Patients are also given varying dosages. The usual dose of Sildenafil is 50mg, while the standard dose of Tadalafil is 10mg. Tadalafil is a better medicine for erectile dysfunction because it has a lower dose and is more potent. Even tadalafil is available in two distinct forms. The daily dose of the medicine formulation is even lower than the standard dose i.e. 2.5mg. This increases the drug’s effectiveness. Although the negative effects of both medications are comparable and can be even worse when used with nitrates, resulting in low blood pressure and heart attacks, tadalafil is associated with fewer deaths than sildenafil.

This medication lasts for 36 hours and can be used daily. Sildenafil should not be used daily due to its negative effects, which arise when the second dose is taken within 24 hours. All of this debate has led to the conclusion that Tadalafil is a more potent and powerful medicine that requires only 10mg to perform well.  Tadalafil is the medicine of choice for ED, and many doctors prescribe it.

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